NIH VideoCast - Pathogenic pathways in allergy gleaned from monogenic disease

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Pathogenic pathways in allergy gleaned from monogenic disease

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Air date:	Friday, November 14, 2014, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 217 (38 Live, 179 On-demand)
Category:	NIH Director's Seminars
Runtime:	00:54:02
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Director's Seminar Series Monogenic diseases can be highly instructive in uncovering basic pathways whose perturbations lead to specific symptoms. Monogenic diseases associated with allergy present an opportunity to define pathways critical for preventing allergic disease. Previous studies of such diseases have understandably focused on the more severe associated phenotypes such as infection, autoimmunity or neoplasms. Our lab wishes to mechanistically understand how these mutations lead to the allergic phenotype, in order to learn globally important lessons in allergy pathogenesis. Additionally, we seek to define new genetic diseases of allergy by focusing on allergic symptoms as the inherited trait, and carefully examining more subtle phenotypes which may not have been brought to the attention of a medical professional, but provide invaluable tools in identifying novel disorders. This seminar will focus on several genetic diseases of allergy recently described by our lab along with a known one, and the pathophysiologic insight they have provided.

NLM Title:	Pathogenic pathways in allergy gleaned from monogenic disease / Joshua D. Milner.
Author:	Milner, Joshua D. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): NIH Director's Seminar Series. Monogenic diseases can be highly instructive in uncovering basic pathways whose perturbations lead to specific symptoms. Monogenic diseases associated with allergy present an opportunity to define pathways critical for preventing allergic disease. Previous studies of such diseases have understandably focused on the more severe associated phenotypes such as infection, autoimmunity or neoplasms. Our lab wishes to mechanistically understand how these mutations lead to the allergic phenotype, in order to learn globally important lessons in allergy pathogenesis. Additionally, we seek to define new genetic diseases of allergy by focusing on allergic symptoms as the inherited trait, and carefully examining more subtle phenotypes which may not have been brought to the attention of a medical professional, but provide invaluable tools in identifying novel disorders. This seminar will focus on several genetic diseases of allergy recently described by our lab along with a known one, and the pathophysiologic insight they have provided.
Subjects:	Hypersensitivity--genetics Hypersensitivity--pathology
Publication Types:	Lecture Webcast

NLM Classification:	WD 300
NLM ID:	101647969
CIT Live ID:	15144
Permanent link:	https://videocast.nih.gov/watch=15144

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