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Is Aging Reversible? Resetting the Clock

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Air date: Wednesday, September 12, 2012, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 737, (252 Live, 485 On-demand)
Category: Wednesday Afternoon Lectures
Runtime: 01:02:40
Description: Wednesday Afternoon Lecture Series

The Annual Florence Mahoney Lecture

Aging is a process that is generally viewed as unidirectional, relentless, and inevitable. However, in addition to the existence of non-aging species, or at least species with negligible senescence, data from a wide range of living organisms suggests that environmental influences can markedly slow and even halt the aging process. Furthermore, recent experimental evidence suggests that aspects of the molecular and functional characteristics of aged cells and tissues even in mammals can be restored to a more youthful state. Analyses of age-related changes in cells have revealed clear epigenetic changes, and the reversibility of some of those processes, in essence leading to cell and tissue rejuvenation, suggest epigenetic mechanisms.

Current studies focus on understanding the nature and regulation of those epigenetic mechanisms and the extent to which the aging clock can be rewound or reset by defined environmental influences while leaving other cellular characteristics, such as their state of differentiation, intact.

For more information go to http://wals.od.nih.gov/
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NLM Title: Is aging reversible? : resetting the clock [electronic resource] / Thomas A. Rando.
Series: Wednesday afternoon lecture series. Florence S. Mahoney lecture on aging
Author: Rando, Thomas A.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): Wednesday afternoon lecture series. Florence S. Mahoney lecture on aging
Abstract: (CIT): Wednesday Afternoon Lecture Series. The Annual Florence Mahoney Lecture. Aging is a process that is generally viewed as unidirectional, relentless, and inevitable. However, in addition to the existence of non-aging species, or at least species with negligible senescence, data from a wide range of living organisms suggests that environmental influences can markedly slow and even halt the aging process. Furthermore, recent experimental evidence suggests that aspects of the molecular and functional characteristics of aged cells and tissues even in mammals can be restored to a more youthful state. Analyses of age-related changes in cells have revealed clear epigenetic changes, and the reversibility of some of those processes, in essence leading to cell and tissue rejuvenation, suggest epigenetic mechanisms. Current studies focus on understanding the nature and regulation of those epigenetic mechanisms and the extent to which the aging clock can be rewound or reset by defined environmental influences while leaving other cellular characteristics, such as their state of differentiation, intact.
Subjects: Aging--genetics
Aging--physiology
Cell Aging
Epigenesis, Genetic--physiology
Publication Types: Lectures
Webcasts
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NLM Classification: WT 104
NLM ID: 101595138
CIT Live ID: 11852
Permanent link: http://videocast.nih.gov/launch.asp?17556

 

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