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Metabolic effects of skeletal muscle hypertrophy caused by myostatin inhibition

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Air date: Thursday, May 03, 2012, 11:00:00 AM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 124, (8 Live, 116 On-demand)
Category: Special
Runtime: 01:11:39
Description: Metabolomics Interest Group

Myostatin is a secreted protein produced by skeletal muscle that regulates muscle mass. Myostatin 'knockout' mice, made by deleting the myostatin gene by gene targeting, have a dramatic and widespread increase in skeletal muscle mass. Currently, Dr. McPherron's team is trying to understand how myostatin inhibits skeletal muscle mass at the cellular and molecular level both during development and in adulthood using the mouse as a model system. She will present her team's work on the effects of muscle hypertrophy on metabolism of muscle, fat, liver, and in serum and disucss possible implications of Myostatin inhibitors may be useful therapeutically to treat diabetes or obesity.
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NLM Title: Metabolic effects of skeletal muscle hypertrophy caused by myostatin inhibition [electronic resource] / Alexandra McPherron.
Author: McPherron, Alexandra.
National Institutes of Health (U.S.). Metabolomics Interest Group.
Publisher:
Abstract: (CIT): Metabolomics Interest Group Myostatin is a secreted protein produced by skeletal muscle that regulates muscle mass. Myostatin 'knockout' mice, made by deleting the myostatin gene by gene targeting, have a dramatic and widespread increase in skeletal muscle mass. Currently, Dr. McPherron's team is trying to understand how myostatin inhibits skeletal muscle mass at the cellular and molecular level both during development and in adulthood using the mouse as a model system. She will present her team's work on the effects of muscle hypertrophy on metabolism of muscle, fat, liver, and in serum and discuss possible implications of myostatin inhibitors may be useful therapeutically to treat diabetes or obesity.
Subjects: Hypertrophy--metabolism
Muscle, Skeletal--drug effects
Myostatin--therapeutic use
Publication Types: Lectures
Webcasts
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Caption Text: Download Caption File
NLM Classification: QZ 190
NLM ID: 101585252
CIT Live ID: 11279
Permanent link: http://videocast.nih.gov/launch.asp?17247