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The tip of the therapeutic iceberg: Expanding the G protein-coupled receptor pharmacopeia

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Air date: Thursday, April 12, 2012, 10:00:00 AM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 440 (12 Live, 428 On-demand)
Category: Proteomics
Runtime: 01:09:14
Description: Proteomics Interest Group

Currently nearly half of the therapeutic pharmacopeia is targeted towards the plasma membrane heptahelical G proteincoupled receptors (GPCRs). Once considered to be relatively simplisitc ‘on-off’ systems, these highly flexible receptor proteins appear now to possess a potentially unprecedented level of functional nuance. Our increased appreciation of this specific receptor system is undoubtedly one of the most important fields of future translational research for the NIH.
NLM Title: The tip of the therapeutic iceberg : expanding the G protein-coupled receptor pharmacopeia / Stuart Maudsley ; Proteomics Interest Group.
Author: Maudsley, Stuart.
National Institutes of Health (U.S.). Proteomics Interest Group.
Publisher:
Abstract: (CIT): Currently nearly half of the therapeutic pharmacopeia is targeted towards the plasma membrane heptahelical G proteincoupled receptors (GPCRs). Once considered to be relatively simplisitc "on-off" systems, these highly flexible receptor proteins appear now to possess a potentially unprecedented level of functional nuance. Our increased appreciation of this specific receptor system is undoubtedly one of the most important fields of future translational research for the NIH.
Subjects: Drug Discovery
Receptors, G-Protein-Coupled--physiology
Publication Types: Lecture
Webcast
 
NLM Classification: QV 36
NLM ID: 101585228
CIT Live ID: 11155
Permanent link: https://videocast.nih.gov/watch=11155

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