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Currently nearly half of the therapeutic pharmacopeia is targeted towards the plasma membrane heptahelical G proteincoupled receptors (GPCRs). Once considered to be relatively simplisitc ‘on-off’ systems, these highly flexible receptor proteins appear now to possess a potentially unprecedented level of functional nuance. Our increased appreciation of this specific receptor system is undoubtedly one of the most important fields of future translational research for the NIH.
Runtime:
01:09:14
NLM Title:
The tip of the therapeutic iceberg : expanding the G protein-coupled receptor pharmacopeia [electronic resource] / Stuart Maudsley ; Proteomics Interest Group.
Author:
Maudsley, Stuart. National Institutes of Health (U.S.). Proteomics Interest Group.
Publisher:
[Bethesda, Md. : National Institutes of Health, 2012]
Abstract:
(CIT): Currently nearly half of the therapeutic pharmacopeia is targeted towards the plasma membrane heptahelical G proteincoupled receptors (GPCRs). Once considered to be relatively simplisitc "on-off" systems, these highly flexible receptor proteins appear now to possess a potentially unprecedented level of functional nuance. Our increased appreciation of this specific receptor system is undoubtedly one of the most important fields of future translational research for the NIH.
Subjects:
Drug Discovery Receptors, G-Protein-Coupled--physiology
