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Plasticity and Regeneration in the CNS; the Role of the Extracellular Matrix

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Air date: Monday, March 19, 2012, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 325, (21 Live, 304 On-demand)
Category: Neuroscience
Runtime: 01:02:26
Description: Neuroscience Seminar Series

Dr. Fawcett's Lab work concerns the role of extracellular matrix proteoglycans in the central nervous system. In the damaged CNS, they are trying to understand how axonal growth is inhibited by the increased expression of inhibitory proteoglycans, and how to overcome this inhibition. They work on how to increase the intrinsic regenerative potential of axons, using integrin engineering and local protein translation. In addition, plasticity is turned off in adults by extracellular matrix structures called perineuronal nets. They work on the actions of these structures, and methods to modulate their function so as to improve functional recovery and memory in the adult CNS.

For more information go to http://neuroseries.info.nih.gov
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NLM Title: Plasticity and regeneration in the CNS : the role of the extracellular matrix [electronic resource] / James Fawcett.
Series: Neuroscience seminar series
Author: Fawcett, James W.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): Neuroscience seminar series
Abstract: (CIT): Neuroscience Seminar Series Dr. Fawcett's Lab work concerns the role of extracellular matrix proteoglycans in the central nervous system. In the damaged CNS, they are trying to understand how axonal growth is inhibited by the increased expression of inhibitory proteoglycans, and how to overcome this inhibition. They work on how to increase the intrinsic regenerative potential of axons, using integrin engineering and local protein translation. In addition, plasticity is turned off in adults by extracellular matrix structures called perineuronal nets. They work on the actions of these structures, and methods to modulate their function so as to improve functional recovery and memory in the adult CNS. For more information go to http://neuroseries.info.nih.gov.
Subjects: Extracellular Matrix--physiology
Nerve Regeneration--physiology
Neuronal Plasticity--physiology
Publication Types: Lectures
Webcasts
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Caption Text: Download Caption File
NLM Classification: WL 102
NLM ID: 101581488
CIT Live ID: 11009
Permanent link: http://videocast.nih.gov/launch.asp?17175