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Objectives
Define the functional differences between anti-inflammation versus pro-resolution and the cell types involved;
Define the anti-inflammatory and pro-resolving lipid mediators;
Review the biosynthesis and omega-3 precursors (EPA and DHA) of the resolvins, protectins and maresins (E-series vs. D-series resolvins) and their actions;
Define the resolution indices: what enhances resolution and the drugs that are resolution toxic; and
What are the key cellular targets of the resolvins and mechanism(s) (e.g. receptors, miR, etc.) that define resolving autacoids in animal inflammatory diseases.
