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Anthrax Toxin: Structure, Activity, and New Inhibitors

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Air date: Monday, October 07, 2002, 9:00:00 AM
Time displayed is Eastern Time, Washington DC Local
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Category: Joseph J. Kinyoun
Runtime: 01:02:02
Description: Kinyoun Lecture

R. John Collier, Ph.D.
Professor, Microbiology and Molecular Genetics
Harvard Medical School

Dr. Collier has devoted his career to understanding the molecular mechanisms by which bacteria cause disease. His research has elucidated the structures and modes of action of bacterial protein toxins, and he has applied this knowledge to develop novel approaches to treat and prevent diseases. Early in his career Collier discovered that diphtheria toxin (DT) inhibits protein synthesis by directly inactivating a eukaryotic polypeptide elongation factor (elongation factor-2) within the cytosol. Besides explaining the mode of action of DT, this represented the first demonstration that a bacterial protein toxin could breach a membrane protecting the mammalian cytosol from the extracellular milieu. This finding changed thinking about how protein toxins act.
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Author: R. John Collier, Ph.D., Harvard Medical School
Rights: This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely.
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CIT Live ID: 1766
Permanent link: http://videocast.nih.gov/launch.asp?17044