NIH VideoCast - G Protein Signaling to Neuronal Calcium Channels Directed by Cell-Specific Alternative Splicing

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G Protein Signaling to Neuronal Calcium Channels Directed by Cell-Specific Alternative Splicing

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Air date:	Monday, November 7, 2011, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 361 (32 Live, 329 On-demand)
Category:	Neuroscience
Runtime:	01:13:44
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Neuroscience Seminar Series Dr. Lipscombe's lab is interested in the cellular mechanisms used to optimize calcium ion channel function. Calcium ion channels regulate many critical neuronal functions including transmitter release, nerve growth, and synaptic plasticity. Their current research focus is on cell-specific alternative splicing in the mammalian nervous system. They study cellular mechanisms that control calcium channel function in normal as well as in disease states, including chronic pain and mental illness. Voltage-gated calcium channels, the gatekeepers of excitation-driven calcium entry in all excitable cells, control a diverse array of functions. Alternative splicing expands functional capabilities and contributes greatly to the expansion of the proteome required to support complex brain functions. They study alternative splicing of voltage-gated calcium channels. Their work is relevant to basic mechanisms that control channel function in normal and in disease states, including chronic pain. For more information, visit: http://neuroseries.info.nih.gov

NLM Title:	G protein signaling to neuronal calcium channels directed by cell-specific alternative splicing / Diane Lipscombe.
Author:	Lipscombe, Diane. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): Neuroscience Seminar Series. Dr. Lipscombe's lab is interested in the cellular mechanisms used to optimize calcium ion channel function. Calcium ion channels regulate many critical neuronal functions including transmitter release, nerve growth, and synaptic plasticity. Their current research focus is on cell-specific alternative splicing in the mammalian nervous system. They study cellular mechanisms that control calcium channel function in normal as well as in disease states, including chronic pain and mental illness. Voltage-gated calcium channels, the gatekeepers of excitation-driven calcium entry in all excitable cells, control a diverse array of functions. Alternative splicing expands functional capabilities and contributes greatly to the expansion of the proteome required to support complex brain functions. They study alternative splicing of voltage-gated calcium channels. Their work is relevant to basic mechanisms that control channel function in normal and in disease states, including chronic pain.
Subjects:	Alternative Splicing Calcium Channels, N-Type GTP-Binding Proteins
Publication Types:	Lecture Webcast

NLM Classification:	QU 55.7
NLM ID:	101574475
CIT Live ID:	10642
Permanent link:	https://videocast.nih.gov/watch=10642

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