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Bound and Determined: Cell Fate in Health and Disease

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Air date: Wednesday, June 15, 2011, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 187 * This only includes stats from October 2011 and forward.
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:04:01
Description: We have previously shown that mice lacking the adaptor protein Schnurri-3 display a profound high bone mass phenotype due to augmented anabolic bone formation. In addition to regulating bone formation by osteoblasts in a cell-intrinsic manner, Shn3 indirectly controls bone resorption in vivo. In most instances, bone formation is coupled with bone resorption, which limits the efficacy of the currently marked anti-resorptives. However, in this instance, we demonstrate that these two processes can be uncoupled by genetic manipulation of Shn3 raising the possibility that its inhibition would be beneficial in the setting of diseases of low bone mass such as osteoporosis. We have recently used both unbiased and Schnurri-3 biased forward genetic RNAi screens coupled with extensive gene profiling analyses to assemble a picture of osteoblast signaling pathways proximal to or instigated by Schnurri3. These analyses have provided novel targets in osteoblasts that control adult bone mass.

The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

For more information, visit:
The NIH Director's Wednesday Afternoon Lecture Series
NLM Title: Bound and determined : cell fate in health and disease / Laurie Glimcher.
Author: Glimcher, Laurie.
National Institutes of Health (U.S.)
Publisher:
Abstract: (CIT): We have previously shown that mice lacking the adaptor protein Schnurri-3 display a profound high bone mass phenotype due to augmented anabolic bone formation. In addition to regulating bone formation by osteoblasts in a cell-intrinsic manner, Shn3 indirectly controls bone resorption in vivo. In most instances, bone formation is coupled with bone resorption, which limits the efficacy of the currently marked anti-resorptives. However, in this instance, we demonstrate that these two processes can be uncoupled by genetic manipulation of Shn3 raising the possibility that its inhibition would be beneficial in the setting of diseases of low bone mass such as osteoporosis. We have recently used both unbiased and Schnurri-3 biased forward genetic RNAi screens coupled with extensive gene profiling analyses to assemble a picture of osteoblast signaling pathways proximal to or instigated by Schnurri3. These analyses have provided novel targets in osteoblasts that control adult bone mass. The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. For more information, visit: The NIH Director's Wednesday Afternoon Lecture Series.
Subjects: Bone and Bones--metabolism
DNA-Binding Proteins
Immunity, Cellular
Publication Types: Lecture
Webcast
NLM Classification: WE 200
NLM ID: 101565225
CIT Live ID: 10297
Permanent link: https://videocast.nih.gov/watch=10297

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