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Genetic Studies of Telencephalon Development

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Air date: Monday, April 04, 2011, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
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Category: Neuroscience
Runtime: 00:56:44
Description: Neuroscience Seminar Series

The goal of Dr. Rubenstein’s research is to elucidate fundamental mechanisms that regulate development of the forebrain and in parallel, whether disruption of these mechanisms underlie human disorders, such as autism, schizophrenia, mental retardation, epilepsy and craniofacial disorders. Investigations include studies on secreted factors, such as Fgf8 and Fgf17, that function in regionalization of the neural plate and cerebral cortex. They have shown that Fgf17 mutant mice have hypoplasia of their anterior cingulate gyrus, and behavioral deficits in social interactions. Ongoing studies also focus on defining transcription factors that control CNS development, including Nkx genes (specifying ventral neural progenitors) and Dlx1 and 2 (involved in differentiation of GABAergic neurons). In addition, Dr. Rubenstein has been involved in investigations on tangential migration in the CNS. Studying the migration of GABAergic neurons from the subcortical telencephalon into the cerebral cortex, both factors controlling movement of the cells as well as integration of the cells once they reach their destination. Finally, the lab has a longstanding clinical interest in Autism, with work focused on sequencing of candidate genes and functional analyses of mutant alleles.

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NLM Title: Genetic studies of telencephalon development [electronic resource] / John Rubenstein.
Series: NIH neuroscience seminar series
Author: Rubenstein, John L.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): NIH neuroscience seminar series
Abstract: (CIT): The goal of Dr. Rubenstein's research is to elucidate fundamental mechanisms that regulate development of the forebrain and in parallel, whether disruption of these mechanisms underlie human disorders, such as autism, schizophrenia, mental retardation, epilepsy and craniofacial disorders. Investigations include studies on secreted factors, such as Fgf8 and Fgf17, that function in regionalization of the neural plate and cerebral cortex. They have shown that Fgf17 mutant mice have hypoplasia of their anterior cingulate gyrus, and behavioral deficits in social interactions. Ongoing studies also focus on defining transcription factors that control CNS development, including Nkx genes (specifying ventral neural progenitors) and Dlx1 and 2 (involved in differentiation of GABAergic neurons). In addition, Dr. Rubenstein has been involved in investigations on tangential migration in the CNS. Studying the migration of GABAergic neurons from the subcortical telencephalon into the cerebral cortex, both factors controlling movement of the cells as well as integration of the cells once they reach their destination. Finally, the lab has a longstanding clinical interest in Autism, with work focused on sequencing of candidate genes and functional analyses of mutant alleles.
Subjects: Mice
Models, Animal
Telencephalon--growth & development
Publication Types: Lectures
Webcasts
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Caption Text: Download Caption File
NLM Classification: WL 307
NLM ID: 101559825
CIT Live ID: 10130
Permanent link: http://videocast.nih.gov/launch.asp?16567

 

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