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Sex Differences in Drug Abuse: The Role of Estradiol

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Air date: Wednesday, December 15, 2010, 11:00:00 AM
Time displayed is Eastern Time, Washington DC Local
Category: BSSR Lecture Series
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Description: BSSR Lecture Series

There are sex differences in many motivated behaviors, including the motivation to take drugs of abuse. In females, rapid effects of estradiol on the ascending dopamine (DA) system enhance the female's motivation to take cocaine and other drugs of abuse. These effects of estradiol can be studied behaviorally and neurochemically when looking at the response to psychomotor stimulant drugs such as cocaine and amphetamine. For example, we have found that female rats exhibit greater behavioral sensitization to cocaine, acquire cocaine self-administration more rapidly, and work harder for access to cocaine than males. Estradiol enhances these sex differences. In the striatum and nucleus accumbens, estradiol rapidly potentiates stimulated DA release of female rats. Results from experiments investigating the mechanisms mediating this effect of estradiol will also be discussed.
Author: Jill B. Becker, PhD
Runtime: 01:04:53
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CIT File ID: 16351
CIT Live ID: 9843
Permanent link: http://videocast.nih.gov/launch.asp?16351

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