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Sex Differences in Drug Abuse: The Role of Estradiol

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Air date: Wednesday, December 15, 2010, 11:00:00 AM
Time displayed is Eastern Time, Washington DC Local
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Category: BSSR Lecture Series
Runtime: 01:04:53
Description: BSSR Lecture Series

There are sex differences in many motivated behaviors, including the motivation to take drugs of abuse. In females, rapid effects of estradiol on the ascending dopamine (DA) system enhance the female's motivation to take cocaine and other drugs of abuse. These effects of estradiol can be studied behaviorally and neurochemically when looking at the response to psychomotor stimulant drugs such as cocaine and amphetamine. For example, we have found that female rats exhibit greater behavioral sensitization to cocaine, acquire cocaine self-administration more rapidly, and work harder for access to cocaine than males. Estradiol enhances these sex differences. In the striatum and nucleus accumbens, estradiol rapidly potentiates stimulated DA release of female rats. Results from experiments investigating the mechanisms mediating this effect of estradiol will also be discussed.
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NLM Title: Sex differences in drug abuse : the role of estradiol [electronic resource] / Jill B. Becker.
Series: BSSR lecture series
Author: Becker, Jill B.
National Institutes of Health (U.S.). Office of Behavioral and Social Sciences Research.
Publisher:
Other Title(s): BSSR lecture series
Abstract: (CIT): There are sex differences in many motivated behaviors, including the motivation to take drugs of abuse. In females, rapid effects of estradiol on the ascending dopamine (DA) system enhance the female's motivation to take cocaine and other drugs of abuse. These effects of estradiol can be studied behaviorally and neurochemically when looking at the response to psychomotor stimulant drugs such as cocaine and amphetamine. For example, we have found that female rats exhibit greater behavioral sensitization to cocaine, acquire cocaine self-administration more rapidly, and work harder for access to cocaine than males. Estradiol enhances these sex differences. In the striatum and nucleus accumbens, estradiol rapidly potentiates stimulated DA release of female rats. Results from experiments investigating the mechanisms mediating this effect of estradiol will also be discussed.
Subjects: Estradiol
Sex Factors
Substance-Related Disorders--epidemiology
Publication Types: Lectures
Webcasts
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NLM Classification: WM 270
NLM ID: 101552205
CIT Live ID: 9843
Permanent link: http://videocast.nih.gov/launch.asp?16351