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Mouse Genetic Models of Autism-Related Traits: How Do We Know When We Have One?

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Air date: Monday, October 25, 2010, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
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Category: Neuroscience
Runtime: 01:07:20
Description: Dr. Paylor is a leader in developing and implementing behavioral test batteries for the analysis of mutant mice. In particular, he is well recognized for his research directed towards the behavioral characterization of mouse genetic models of neurodevelopmental disorders including Fragile X, Williams-Beuren, Rett, DiGeorge, and Smith-Magenis syndromes. New findings from his lab have shown that both pharmacological and genetic manipulations can alter several behavioral responses in the mouse model of Fragile X. Dr. Paylor has also identified a novel transgenic mouse model with unique molecular alterations resulting in multiple autistic-like traits. Recently, Dr. Paylor’s lab has initiated a project with the long-term goal to employ the R6/2 transgenic mice to identify putative genetic/molecular modifiers of Huntington’s Disease, which could lead to potential targets for therapeutic intervention.

NIH Neuroscience Seminar Series
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NLM Title: Mouse genetic models of autism-related traits : how do we know when we have one? [electronic resource] / Richard E. Paylor.
Series: NIH neuroscience series
Author: Paylor, Richard E.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): NIH neuroscience series
Abstract: (CIT): Dr. Paylor is a leader in developing and implementing behavioral test batteries for the analysis of mutant mice. In particular, he is well recognized for his research directed towards the behavioral characterization of mouse genetic models of neurodevelopmental disorders including Fragile X, Williams-Beuren, Rett, DiGeorge, and Smith-Magenis syndromes. New findings from his lab have shown that both pharmacological and genetic manipulations can alter several behavioral responses in the mouse model of Fragile X. Dr. Paylor has also identified a novel transgenic mouse model with unique molecular alterations resulting in multiple autistic-like traits. Recently, Dr. Paylor"s lab has initiated a project with the long-term goal to employ the R6/2 transgenic mice to identify putative genetic/molecular modifiers of Huntington"s Disease, which could lead to potential targets for therapeutic intervention.
Subjects: Autistic Disorder--diagnosis
Mice
Models, Genetic
Publication Types: Lectures
Webcasts
Download: To download this event, select one of the available bitrates:
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NLM Classification: WM 203.5
NLM ID: 101549217
CIT Live ID: 9484
Permanent link: http://videocast.nih.gov/launch.asp?16222

 

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