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Being Energetic About Mitochondrial Proteomics

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Air date: Wednesday, October 06, 2010, 1:00:00 PM
Time displayed is Eastern Time, Washington DC Local
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Category: Mitochondria
Runtime: 02:20:37
Description: The mitochondria are multi-faceted organelles involved in cellular processes such as energetics, survival, and signal transduction. These processes may be altered in various environmental conditions and disease states. Although mitochondria have their own genome, much of the mitochondrial proteome is encoded by nuclear DNA and then imported to the organelles. It is being observed that mitochondrial proteomes vary under cell context in both the type of proteins present and post-translational modifications. Because each organ has various energetic and homeostatic requirements, this implies mitochondria have adapted to needs of specialized cells. Studies into mitochondrial proteomes are bringing novel insights into how mitochondrial function and under what circumstances they become dysfunctional. These sessions will highlight proteomics in mitochondrial research with relevance to toxicology and disease.
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NLM Title: Being energetic about mitochondrial proteomics [electronic resource] / NIH Mitochondria Interest Group.
Author: National Institutes of Health (U.S.). Mitochondria Interest Group.
Publisher:
Abstract: (CIT): The mitochondria are multi-faceted organelles involved in cellular processes such as energetics, survival, and signal transduction. These processes may be altered in various environmental conditions and disease states. Although mitochondria have their own genome, much of the mitochondrial proteome is encoded by nuclear DNA and then imported to the organelles. It is being observed that mitochondrial proteomes vary under cell context in both the type of proteins present and post-translational modifications. Because each organ has various energetic and homeostatic requirements, this implies mitochondria have adapted to needs of specialized cells. Studies into mitochondrial proteomes are bringing novel insights into how mitochondrial function and under what circumstances they become dysfunctional. These sessions will highlight proteomics in mitochondrial research with relevance to toxicology and disease.
Subjects: Mitochondria--physiology
Mitochondrial Proteins--physiology
Proteomics
Publication Types: Lectures
Webcasts
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NLM Classification: QU 58.5
NLM ID: 101549183
CIT Live ID: 9687
Permanent link: http://videocast.nih.gov/launch.asp?16183

 

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