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The mitochondria are multi-faceted organelles involved in cellular processes such as energetics, survival, and signal transduction. These processes may be altered in various environmental conditions and disease states. Although mitochondria have their own genome, much of the mitochondrial proteome is encoded by nuclear DNA and then imported to the organelles. It is being observed that mitochondrial proteomes vary under cell context in both the type of proteins present and post-translational modifications. Because each organ has various energetic and homeostatic requirements, this implies mitochondria have adapted to needs of specialized cells. Studies into mitochondrial proteomes are bringing novel insights into how mitochondrial function and under what circumstances they become dysfunctional. These sessions will highlight proteomics in mitochondrial research with relevance to toxicology and disease.
Runtime:
02:20:37
NLM Title:
Being energetic about mitochondrial proteomics [electronic resource] / NIH Mitochondria Interest Group.
Author:
National Institutes of Health (U.S.). Mitochondria Interest Group.
Publisher:
[Bethesda, Md. : National Institutes of Health, 2010]
Abstract:
(CIT): The mitochondria are multi-faceted organelles involved in cellular processes such as energetics, survival, and signal transduction. These processes may be altered in various environmental conditions and disease states. Although mitochondria have their own genome, much of the mitochondrial proteome is encoded by nuclear DNA and then imported to the organelles. It is being observed that mitochondrial proteomes vary under cell context in both the type of proteins present and post-translational modifications. Because each organ has various energetic and homeostatic requirements, this implies mitochondria have adapted to needs of specialized cells. Studies into mitochondrial proteomes are bringing novel insights into how mitochondrial function and under what circumstances they become dysfunctional. These sessions will highlight proteomics in mitochondrial research with relevance to toxicology and disease.
