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To understand the contribution of high risk alleles and low penetrant genes;
To emphasize primary prevention strategies for familial breast cancer; and
To explore interventions for breast cancer prevention, including lifestyle and nutritional approaches.
Dr. Olopade's interest in bridging the gaps between clinical services, translational research, and basic science investigations in cancer genetics led to the establishment of the Center for Clinical Cancer Genetics at the University of Chicago. By establishing and maintaining a large and growing database of high-risk individuals, her team is able to examine the contribution of germline BRCA1 and BRCA2 mutations in diverse populations. Dr. Olopade's laboratory was the first to describe recurrent BRCA1 mutations in extended African American families with breast cancer, a study that they extended to the founder population of African Americans in West Africa. They found that breast cancers in African women often produce a pattern of gene expression that is significantly different from that seen in Caucasians.
This lecture series features extraordinary contributors or "stars" in the field of cancer and nutrition research. Speakers highlight the important role that nutrition plays in modifying cancer development. The lectures aim to facilitate interdisciplinary interactions among basic scientists, clinicians, and behavioral and social scientists. Lectures typically occur each fall and spring.