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Dr. Gertler has made fundamental contributions to our understanding of the relationship of signal transduction to cell motility, particularly in axon growth and guidance. He identified the founding member of the ENA/VASP family of proteins, encoded by the Drosophila gene enabled, as well as its mouse ortholog, MENA, and he has been a pioneer in uncovering the central role these proteins play in control of actin organization and dynamics. This work has been instrumental in shaping our view of how cell morphology and motility arises from the complex dynamics of the actin cytoskeleton.
