NIH VideoCast - The Th2 environment and autoimmunity: Making sense of IgE in lupus

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The Th2 environment and autoimmunity: Making sense of IgE in lupus

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Air date:	Wednesday, January 6, 2010, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 140 * This only includes stats from October 2011 and forward.
Category:	Immunology
Runtime:	00:53:09
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	The first seminar of the new year features one of our own, Dr. Nicolas Charles of the Laboratory of Molecular Immunogenetics of NIAMS. As a native of France, Nico appropriately began his scientific career working towards the discovery of new molecules to combat cryptogamic diseases of the grapevine. He then started his PhD studies in the laboratory of Boris Vargaftig at the Institut Pasteur but subsequently moved to Xavier Bichat Medical School in Paris with his mentor, Marc Benhamou. During his PhD studies, Nico discovered that phospholipid scramblase and p28 are part of the high affinity IgE receptor signal transduction cascade and showed that phospholipid scramblase is activated by the IgE receptor and is required for normal mast cell degranulation, a previously unrecognized role for this family of proteins. Nico received his PhD in 2005 and subsequently came to the NIH to work in the Laboratory of Molecular Immunogenetics with Juan Rivera. Since his arrival he has explored whether there exists a relationship between allergic and autoimmune diseases. In recently published work (Immunity 30:533-543, 2009), Nico found that basophils control the Th2 differentiation and that basophil-expressed Lyn kinase is necessary to govern the extent of Th2 differentiation and response. In more recent work he has uncovered a connection between the dysregulation of the Th2 environment and lupus nephritis. This provocative finding is supported by preliminary studies in SLE patients. Don’t miss this exciting presentation! The Immunology Interest Group

NLM Title:	The Th2 environment and autoimmunity : making sense of IgE in lupus / Nicolas Charles ; Immunology Interest Group.
Author:	Charles, Nicolas. National Institutes of Health (U.S.). Immunology Interest Group.
Publisher:
Abstract:	(CIT): The first seminar of the new year features one of our own, Dr. Nicolas Charles of the Laboratory of Molecular Immunogenetics of NIAMS. As a native of France, Nico appropriately began his scientific career working towards the discovery of new molecules to combat cryptogamic diseases of the grapevine. He then started his PhD studies in the laboratory of Boris Vargaftig at the Institut Pasteur but subsequently moved to Xavier Bichat Medical School in Paris with his mentor, Marc Benhamou. During his PhD studies, Nico discovered that phospholipid scramblase and p28 are part of the high affinity IgE receptor signal transduction cascade and showed that phospholipid scramblase is activated by the IgE receptor and is required for normal mast cell degranulation, a previously unrecognized role for this family of proteins. Nico received his PhD in 2005 and subsequently came to the NIH to work in the Laboratory of Molecular Immunogenetics with Juan Rivera. Since his arrival he has explored whether there exists a relationship between allergic and autoimmune diseases. In recently published work (Immunity 30:533-543, 2009), Nico found that basophils control the Th2 differentiation and that basophil-expressed Lyn kinase is necessary to govern the extent of Th2 differentiation and response. In more recent work he has uncovered a connection between the dysregulation of the Th2 environment and lupus nephritis. This provocative finding is supported by preliminary studies in SLE patients.
Subjects:	Immunoglobulin E--immunology Lupus Erythematosus, Systemic--immunology Th2 Cells--immunology
Publication Types:	Lecture Webcast
NLM Classification:	WD 380
NLM ID:	101524371
CIT Live ID:	8329
Permanent link:	https://videocast.nih.gov/watch=8329

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