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The Novel Physiology of Bone

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Air date: Wednesday, December 09, 2009, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
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Category: Wednesday Afternoon Lectures
Runtime: 00:56:10
Description: The lab aims at using mouse genetics to identify novel functional connections between organs and new physiologies that are relevant to human. The overarching assumption explaining all the projects currently ongoing in the laboratory is that there are many new physiological pathways to be discovered in mammals. Our aim is not so much to identify novel regulatory molecules involved in known functions but rather to identify, study and elucidate molecularly totally novel functions or made of regulation for various organs. To test this hypothesis we use skeleton as an organ and the mouse as a model organism. In particular we have hypothesized based on an evolutionary and clinically-based view of bone modeling and remodeling, the physiological functions whereby bone tissue is constantly renewed that there must be a common endocrine control of bone mass and energy metabolism. We have then embarked in a systematic effort to identify the molecules implicated in this co-regulation, to define the pathways in which they are ordered and to explore whether the skeleton affects in an endocrine manner other organs and functions than bone remodeling and bone mineralization.

The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
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NLM Title: The novel physiology of bone [electronic resource] / Gerard Karsenty.
Series: NIH director's Wednesday afternoon lecture series
Author: Karsenty, Gerard.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): NIH director's Wednesday afternoon lecture series
Abstract: (CIT): The lab aims at using mouse genetics to identify novel functional connections between organs and new physiologies that are relevant to human. The overarching assumption explaining all the projects currently ongoing in the laboratory is that there are many new physiological pathways to be discovered in mammals. Our aim is not so much to identify novel regulatory molecules involved in known functions but rather to identify, study and elucidate molecularly totally novel functions or made of regulation for various organs. To test this hypothesis we use skeleton as an organ and the mouse as a model organism. In particular we have hypothesized based on an evolutionary and clinically-based view of bone modeling and remodeling, the physiological functions whereby bone tissue is constantly renewed that there must be a common endocrine control of bone mass and energy metabolism. We have then embarked in a systematic effort to identify the molecules implicated in this co-regulation, to define the pathways in which they are ordered and to explore whether the skeleton affects in an endocrine manner other organs and functions than bone remodeling and bone mineralization. The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Subjects: Bone and Bones--metabolism
Bone and Bones--physiology
Energy Metabolism--physiology
Publication Types: Lectures
Webcasts
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NLM Classification: WE 200
NLM ID: 101522190
CIT Live ID: 8228
Permanent link: http://videocast.nih.gov/launch.asp?15495

 

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