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Fever is a fundamental sign of inflammation, and hereditary disorders that present with recurrent fever provide a unique opportunity to understand the human biology of inflammation. Stimulated by encounters with patients suffering from hereditary recurrent fevers and utilizing the tools of modern genetics and genomics, it has been possible to identify new genes, gene families, and biochemical pathways that control inflammation, and to discover new meaning for genes and proteins already in the inflammatory lexicon. In some cases, these discoveries have not only given molecular explanations and suggested targeted therapies for the patients we see today, but have shed light on the histories of human populations and their possible evolving interactions with microbial pathogens.
Please note: The patient interview included in this presentation was added after the original taping due to technical difficulties the day of the lecture.
Fevers, genes, and histories : adventures in the genomics of inflammation [electronic resource] / Daniel Kastner.
Series:
NIH director's Wednesday afternoon lecture series
Author:
Kastner, Dan. National Institutes of Health (U.S.)
Publisher:
[Bethesda, Md. : National Institutes of Health, 2009]
Other Title(s):
NIH director's Wednesday afternoon lecture series
Abstract:
(CIT): Fever is a fundamental sign of inflammation, and hereditary disorders that present with recurrent fever provide a unique opportunity to understand the human biology of inflammation. Stimulated by encounters with patients suffering from hereditary recurrent fevers and utilizing the tools of modern genetics and genomics, it has been possible to identify new genes, gene families, and biochemical pathways that control inflammation, and to discover new meaning for genes and proteins already in the inflammatory lexicon. In some cases, these discoveries have not only given molecular explanations and suggested targeted therapies for the patients we see today, but have shed light on the histories of human populations and their possible evolving interactions with microbial pathogens. The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
