NIH VideoCast - Neurobiology of Rett Syndrome and Related Disorders

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Neurobiology of Rett Syndrome and Related Disorders

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Air date:	Wednesday, June 17, 2009, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 146 * This only includes stats from October 2011 and forward.
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:07:18
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Rett syndrome is a postnatal developmental disorder characterized by stagnation of normal development and loss of acquired skills by 12-18 months of age. Although Rett syndrome is sporadic in over 99% of the cases, it is a genetic disorder caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2). Loss of MeCP2 function in ~50% of neurons (due to random X chromosome inactivation [XCI]), causes classic Rett syndrome which is characterized by loss of language and social interaction skills, cognitive impairment, balance problems, seizures, tremors, stereotyped repetitive hand movements, and autonomic dysfunction. Girls with favorable XCI patterns manifest only partial features of the syndrome and may present with either classic autism or mild mental retardation with or without seizures and tremors. Doubling of MeCP2 levels also causes a progressive neurological syndrome that shows overlapping features with Rett syndrome. The use of accurate genetic models of Rett and the duplication syndrome is providing insight about the pathogenic effects of MeCP2 dysfunction. Data demonstrating the mechanism underlying the duplication phenotype, the role of MeCP2 in specific neurons, and the transcriptional alterations resulting from MeCP2 dysfunction will be presented The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

NLM Title:	Neurobiology of Rett syndrome and related disorders / Huda Zoghbi.
Author:	Zoghbi, Huda. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): Rett syndrome is a postnatal developmental disorder characterized by stagnation of normal development and loss of acquired skills by 12-18 months of age. Although Rett syndrome is sporadic in over 99% of the cases, it is a genetic disorder caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2). Loss of MeCP2 function in ~50% of neurons (due to random X chromosome inactivation [XCI]), causes classic Rett syndrome which is characterized by loss of language and social interaction skills, cognitive impairment, balance problems, seizures, tremors, stereotyped repetitive hand movements, and autonomic dysfunction. Girls with favorable XCI patterns manifest only partial features of the syndrome and may present with either classic autism or mild mental retardation with or without seizures and tremors. Doubling of MeCP2 levels also causes a progressive neurological syndrome that shows overlapping features with Rett syndrome. The use of accurate genetic models of Rett and the duplication syndrome is providing insight about the pathogenic effects of MeCP2 dysfunction. Data demonstrating the mechanism underlying the duplication phenotype, the role of MeCP2 in specific neurons, and the transcriptional alterations resulting from MeCP2 dysfunction will be presented.
Subjects:	Methyl-CpG-Binding Protein 2 Rett Syndrome
Publication Types:	Lecture Webcast
NLM Classification:	WL 359
NLM ID:	101510711
CIT Live ID:	7051
Permanent link:	https://videocast.nih.gov/watch=7051

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