Understanding Angiogenesis through Retinopathy

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Air date:	Wednesday, April 15, 2009, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 145 * This only includes stats from October 2011 and forward.
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	00:52:33
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Proliferative vascular disease of the retina is a major cause of blindness in children (retinopathy of prematurity), in middle aged adults (diabetic retinopathy) and in the elderly (age-related macular degeneration). Oxygen-induced retinopathy in the mouse is a model system for both retinopathy and angiogenesis. Understanding the oxygen-regulated factors acting on the immature retina and those factors normally supplied by the in utero environment and missing after premature birth from helps define critical pathways in normal vascular development, vascular loss and neovascularization. With this model we have explored the role of Hif regulated factors such as VEGF and erythropoietin in vascular survival and the role of omega long chain polyunsaturated fatty acids and IGF-1 missing after preterm birth. The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

NLM Title:	Understanding angiogenesis through retinopathy / Lois Smith.
Author:	Smith, Lois. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): Proliferative vascular disease of the retina is a major cause of blindness in children (retinopathy of prematurity), in middle aged adults (diabetic retinopathy) and in the elderly (age-related macular degeneration). Oxygen-induced retinopathy in the mouse is a model system for both retinopathy and angiogenesis. Understanding the oxygen-regulated factors acting on the immature retina and those factors normally supplied by the in utero environment and missing after premature birth from helps define critical pathways in normal vascular development, vascular loss and neovascularization. With this model we have explored the role of Hif regulated factors such as VEGF and erythropoietin in vascular survival and the role of omega long chain polyunsaturated fatty acids and IGF-1 missing after preterm birth.
Subjects:	Erythropoietin Fatty Acids, Unsaturated Insulin-Like Growth Factor I Retinal Vessels Retinopathy of Prematurity Vascular Endothelial Growth Factor A
Publication Types:	Webcast
NLM Classification:	WW 270
NLM ID:	101503629
CIT Live ID:	7623
Permanent link:	https://videocast.nih.gov/watch=7623

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