NIH VideoCast - Tumor Stroma & The Immune Response

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Tumor Stroma & The Immune Response

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Air date:	Wednesday, March 25, 2009, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 137 * This only includes stats from October 2011 and forward.
Category:	Immunology
Runtime:	01:12:05
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Hans Schreiber has been doing cutting edge work on tumor immunology since the early '80s. Throughout his carrier he has worked to identify the antigenic components of cancer cells and how tumor specific CD8 cells can influence and change tumor immunogenicity. The main focus and novelty of his work, however, is on the role of the tumor stroma in tumor protection as well as tumor rejection by the immune system. Early in the '90s he observed that tumors given as tissues with their established stroma were more difficult to reject than tumor cells given in suspension and that an established subcutaneous tumor was not rejected while a skin graft was, even though both carried the same antigen and were in the same mouse; suggesting a tumor-protected role for the stromal cells. Recently, he found that increasing antigen cross-presentation by tumor stromal cells makes the tumor susceptible to rejection by tumor specific CD8 cells. His talk will focus on the idea that, for optimal tumor rejection, we not only have to attack the tumor cells but also the "normal" stromal cells, and he will dissect the mechanisms of such rejection. His work will change the way we think about how CD8 cells reject tumors. He is a good and energetic speaker with a challenging and engaging personality. For more information, visit The Immunology Interest Group

NLM Title:	Tumor stroma & the immune response / Hans Schreiber.
Author:	Schreiber, Hans. National Institutes of Health (U.S.). Immunology Interest Group.
Publisher:
Abstract:	(CIT): Hans Schreiber has been doing cutting edge work on tumor immunology since the early '80s. Throughout his carrier he has worked to identify the antigenic components of cancer cells and how tumor specific CD8 cells can influence and change tumor immunogenicity. The main focus and novelty of his work, however, is on the role of the tumor stroma in tumor protection as well as tumor rejection by the immune system. Early in the '90s he observed that tumors given as tissues with their established stroma were more difficult to reject than tumor cells given in suspension and that an established subcutaneous tumor was not rejected while a skin graft was, even though both carried the same antigen and were in the same mouse; suggesting a tumor-protected role for the stromal cells. Recently, he found that increasing antigen cross-presentation by tumor stromal cells makes the tumor susceptible to rejection by tumor specific CD8 cells. His talk will focus on the idea that, for optimal tumor rejection, we not only have to attack the tumor cells but also the "normal" stromal cells, and he will dissect the mechanisms of such rejection. His work will change the way we think about how CD8 cells reject tumors. He is a good and energetic speaker with a challenging and engaging personality.
Subjects:	Cell Transformation, Neoplastic--immunology Neoplasms--immunology Stromal Cells--immunology Tumor Microenvironment--physiology
Publication Types:	Lecture Webcast
NLM Classification:	QZ 200
NLM ID:	101501618
CIT Live ID:	7453
Permanent link:	https://videocast.nih.gov/watch=7453

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