Molecular Control of T Cell Development and Regulatory T Cell Function

Loading... Loading video...

Air date:	Wednesday, October 22, 2008, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 155 * This only includes stats from October 2011 and forward.
Category:	Immunology
Runtime:	01:04:24
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Dario Vignali is interested in the regulation of T cell tolerance. In order to study how signaling by the TCR controls T cell responses in vivo he has developed an efficient and rapid system to generate “retrogenic” mice, which are derived from stem cells transduced with retrovirus vectors. By this approach he has generated a large group of mice expressing various combinations of wild-type and mutant ITAMs in the TCR-CD3 complex. A low number of ITAMs resulted in lethal autoimmune disease due to defective negative selection. A high ITAM number correlated with greater T cell proliferation while maintaining central tolerance. In another recent study he has shown that IL-35 is a novel inhibitory cytokine, specifically produced by Treg cells, which contributes for their suppressive activity. Ectopic expression of IL-35 confers regulatory activity on naive T cells, whereas recombinant IL-35 suppresses T-cell proliferation. For more information, visit The Immunology Interest Group

NLM Title:	Molecular control of T cell development and regulatory T cell function / Dario Vignali.
Author:	Vignali, Dario. National Institutes of Health (U.S.). Immunology Interest Group.
Publisher:
Abstract:	(CIT): Dario Vignali is interested in the regulation of T cell tolerance. In order to study how signaling by the TCR controls T cell responses in vivo he has developed an efficient and rapid system to generate "retrogenic" mice, which are derived from stem cells transduced with retrovirus vectors. By this approach he has generated a large group of mice expressing various combinations of wild-type and mutant ITAMs in the TCR-CD3 complex. A low number of ITAMs resulted in lethal autoimmune disease due to defective negative selection. A high ITAM number correlated with greater T cell proliferation while maintaining central tolerance. In another recent study he has shown that IL-35 is a novel inhibitory cytokine, specifically produced by Treg cells, which contributes for their suppressive activity. Ectopic expression of IL-35 confers regulatory activity on naive T cells, whereas recombinant IL-35 suppresses T-cell proliferation.
Subjects:	CD3 Complex Cytokines Interleukins Receptors, Antigen, T-Cell
Publication Types:	Lecture Webcast
NLM Classification:	QW 573
NLM ID:	101488647
CIT Live ID:	7077
Permanent link:	https://videocast.nih.gov/watch=7077

NIH VideoCasting