NIH VideoCast - Class Control: The Other Side of Tolerance

Skip Navigation

Class Control: The Other Side of Tolerance

Loading... Loading video...

Air date:	Wednesday, September 10, 2008, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 340 * This only includes stats from October 2011 and forward.
Category:	Immunology
Runtime:	01:05:49
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	This year’s Opening Speaker for the Immunology Interest Group’s Wednesday afternoon seminar series is Dr. Polly Matzinger from the Laboratory of Cellular and Molecular Immunology. Polly received her Ph.D. from the University of California at San Diego in the laboratory of Dr. Richard Dutton, where she worked on the problem of MHC restriction of T cell receptor recognition and championed the one receptor model for dual recognition. Her postdoctoral work in Dr. Herman Waldmann’s laboratory at Cambridge, UK, focussed her efforts on thymic tolerance, setting the stage for her seminal work at the Basel Institute using professional antigen-presenting cells to demonstrate that developing thymocytes are tolerizable only. In 1989 she moved to the NIH where her focus turned to costimulation and the mechanisms by which the adaptive immune system becomes activated. She proposed the Danger Model in which endogenous alarm signals were viewed as the critical molecular switches for initiating a response following antigen recognition by naïve T cells. She also showed that for full differentiation of CD8 cytotoxic T cell responses, the APCs need to be “licensed” by CD4 T cell interactions. More recently, Polly has turned her attention to class regulation in the immune response and the role of the damaged tissue in determining the response’s effector nature (Th1, Th2, Th17, etc.). In this regard, she has an interesting view on the nature of T regulatory cells in this process, which you may enjoy hearing about. Polly is a cogent and entertaining speaker and her synthesis of this important area of cellular immunology is an ideal way to return from your summer vacation and re-immerse yourself in intellectual pursuits. For more information, visit The Immunology Interest Group

NLM Title:	Class control : the other side of tolerance / Polly Matzinger.
Author:	Matzinger, Polly. National Institutes of Health (U.S.). Immunology Interest Group.
Publisher:
Abstract:	(CIT): More recently, Polly has turned her attention to class regulation in the immune response and the role of the damaged tissue in determining the response's effector nature (Th1, Th2, Th17, etc.). In this regard, she has an interesting view on the nature of T regulatory cells in this process.
Subjects:	Immune System--physiology T-Lymphocytes, Helper-Inducer--physiology T-Lymphocytes, Regulatory--physiology Tissues--immunology
Publication Types:	Lecture Webcast
NLM Classification:	QW 504
NLM ID:	101486657
CIT Live ID:	7074
Permanent link:	https://videocast.nih.gov/watch=7074

Related Videos...