Systems Approach to Death-Survival Signaling in Mammalian Cells

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Air date:	Tuesday, March 20, 2007, 11:00:00 AM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 110 * This only includes stats from October 2011 and forward.
Category:	Special
Runtime:	01:09:43
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Description:	Our lab studies the mammalian signaling circuits that determine the choice between alternate cell fates of continued proliferation or programmed cell death. We focus on pathways activated by binding of EGF, IGF1 and hepatocyte growth factor (HGF) proliferation-survival factors and the TNF, TRAIL and FAS death ligands to their receptors on human and murine cells. We approach these topics from a systems perspective in which measurement and experimental manipulations with RNAi, drugs and knock-in mutations are combined with high throughput measurement and mathematical modeling at levels of abstraction that vary from purely statistical to explicitly mechanistic I will describe recent work on the core apoptosis pathways that regulate executioner caspases, proteases that dismantle dying cells. Caspase normally switch from off to on in an all-or-none process that enforces an unambiguous choice between life and death. http://www.nih.gov/sigs/sysbio

NLM Title:	Systems approach to death-survival signaling in mammalian cells / Peter K. Sorger.
Author:	Sorger, Peter K. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): Our lab studies the mammalian signaling circuits that determine the choice between alternate cell fates of continued proliferation or programmed cell death. We focus on pathways activated by binding of EGF, IGF1 and hepatocyte growth factor (HGF) proliferation-survival factors and the TNF, TRAIL and FAS death ligands to their receptors on human and murine cells. We approach these topics from a systems perspective in which measurement and experimental manipulations with RNAi, drugs and knock-in mutations are combined with high throughput measurement and mathematical modeling at levels of abstraction that vary from purely statistical to explicitly mechanistic I will describe recent work on the core apoptosis pathways that regulate executioner caspases, proteases that dismantle dying cells. Caspase normally switch from off to on in an all-or-none process that enforces an unambiguous choice between life and death.
Subjects:	Apoptosis--physiology Cell Survival--physiology Intercellular Signaling Peptides and Proteins Receptors, Tumor Necrosis Factor--metabolism Signal Transduction Tumor Necrosis Factors--metabolism
Publication Types:	Lecture Webcast
NLM Classification:	QU 375
NLM ID:	101303652
CIT Live ID:	5789
Permanent link:	https://videocast.nih.gov/watch=5789

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