Chromosome Dynamics in Cytokine Gene Expression

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Air date:	Wednesday, March 7, 2007, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 113 * This only includes stats from October 2011 and forward.
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:04:31
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	In the last few years, we have found that regulatory elements on one chromosome associate with genes on another chromosome. The system that we study is the differentiation of naïve, precursor CD4 T cells into different kinds of effector helper T cells. We first observed interchromosomal association of the TH1 ifny locus and TH2 loci, which are mutually exclusively expressed by two subtypes of differentiated T helper cells, precedes differentiation and may act as a checkpoint for T cell fate determination. Since this primary observation, we have found several other cases of into chromosomal associations between different cytokine loci in the naïve T cell precursors. Interestingly, upon TH cell differentiation, these associations are terminated and replaced by interactions between expressed loci. Regulatory elements in one locus appear to play an active role in orchestrating processes across these chromosomes. WALS

NLM Title:	Chromosome dynamics in cytokine gene expression / Richard Flavell.
Author:	Flavell, R A. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): In the last few years, we have found that regulatory elements on one chromosome associate with genes on another chromosome. The system that we study is the differentiation of naïve, precursor CD4 T cells into different kinds of effector helper T cells. We first observed interchromosomal association of the TH1 ifny locus and TH2 loci, which are mutually exclusively expressed by two subtypes of differentiated T helper cells, precedes differentiation and may act as a checkpoint for T cell fate determination. Since this primary observation, we have found several other cases of into chromosomal associations between different cytokine loci in the naïve T cell precursors. Interestingly, upon TH cell differentiation, these associations are terminated and replaced by interactions between expressed loci. Regulatory elements in one locus appear to play an active role in orchestrating processes across these chromosomes.
Subjects:	Cell Differentiation Chromatin Cytokines--genetics Gene Expression Regulation--genetics T-Lymphocytes, Helper-Inducer--cytology
Publication Types:	Lecture Webcast
NLM Classification:	WH 200
NLM ID:	101303637
CIT Live ID:	5191
Permanent link:	https://videocast.nih.gov/watch=5191

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