Transcriptional Control of Immunological Tolerance

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Air date:	Wednesday, April 27, 2005, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 102 * This only includes stats from October 2011 and forward.
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	00:57:50
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Description:	Humans expressing a defective form of the transcription factor autoimmune regulator develop multi-organ autoimmune disease. Mice deficient in aire were engineered in order to test the hypothesis that this transcription factor controls autoimmunity by promoting the ectopic expression of peripheral-tissue antigens in thymic epithelial cells. This hypothesis proved correct as the mutant animals exhibited a variety of autoimmune manifestations, dependent on thymic stromal cells, and reflective of reduced or absent thymic transcription of genes encoding peripheral-tissue antigens. In short, peripheral antigenic self is foreshadowed in the thymus, under the dictates of aire.More recently, the cellular mechanism of aire’s influence on immunological tolerance has been explored. For more information, visit http://www.hms.harvard.edu/dms/immunology/fac_mathis.html WALS

Author:	Diane Mathis, Ph.D., Harvard Medical School
CIT Live ID:	3452
Permanent link:	https://videocast.nih.gov/watch=3452

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