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The STAT3 Transcription Factor as a Cancer Target

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Air date: Wednesday, November 19, 2003, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Category: Wednesday Afternoon Lectures
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Description: For almost 20 years our laboratory has been devoted to how polypeptide ligand-receptor interaction at the cell surface activates genes. Recognition of the STAT transcription factors came from this interest. We continue to pursue how the STATs activate genes, particularly in enhanceosomal configurations. Recently because of its biological importance we have concentrated on STAT3. Our long range goal (? we hope not too optimistic) is to provide information for anti-cancer drug targets. The pathway to this goal follows this logic. STAT3 is persistently active in a large percentage of human cancers and functions to prevent apoptosis of the cancer cell. Dominant negative inhibitors of STAT3 introduced into several different types of cultured human cancer cells cause apoptosis in cancer cells.

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James Darnell
Author: James E. Darnell, Jr., M.D., Rockefeller University
Runtime: 01:11:49
Rights: This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely.
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CIT File ID: 11640
CIT Live ID: 2589
Permanent link: http://videocast.nih.gov/launch.asp?11640

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