Skip Navigation


CIT can broadcast your seminar, conference or meeting live to a world-wide audience over the Internet as a real-time streaming video. The event can be recorded and made available for viewers to watch at their convenience as an on-demand video or a downloadable podcast. CIT can also broadcast NIH-only or HHS-only content.

The STAT3 Transcription Factor as a Cancer Target

Loading video...

 
   
Air date: Wednesday, November 19, 2003, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views:  
Category: Wednesday Afternoon Lectures
Runtime: 01:11:49
Description: For almost 20 years our laboratory has been devoted to how polypeptide ligand-receptor interaction at the cell surface activates genes. Recognition of the STAT transcription factors came from this interest. We continue to pursue how the STATs activate genes, particularly in enhanceosomal configurations. Recently because of its biological importance we have concentrated on STAT3. Our long range goal (? we hope not too optimistic) is to provide information for anti-cancer drug targets. The pathway to this goal follows this logic. STAT3 is persistently active in a large percentage of human cancers and functions to prevent apoptosis of the cancer cell. Dominant negative inhibitors of STAT3 introduced into several different types of cultured human cancer cells cause apoptosis in cancer cells.

For more information, visit
James Darnell
Debug: Show Debug
Author: James E. Darnell, Jr., M.D., Rockefeller University
Rights: This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely.
Download: Download Video    How to download a Videocast
CIT Live ID: 2944
Permanent link: http://videocast.nih.gov/launch.asp?11640